GENIX EGI

COLLAGEN EPITHELIAL

GROWTH INDUCER

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GENIX EGI, collagen membrane for guided epithelial tissue regeneration, triggers and speeds up re-epithelialization process in complex skin lesions such as ulcers, traumas or burns, offering an alternative to a skin graft.

MECHANISM OF ACTION

Re-epithelialization, the final phase of wound healing, is often inhibited or slowed down. Collagen has been shown to have effective chemotactic properties in terms of fibroblast and keratinocyte migration in the wound.

GENIX EGI, a collagen membrane derived from heterologous pericardium, stimulates the keratinocytes to migrate from the edge of the wound through the granulation tissue towards the centre of the lesion, thereby initiating and keeping the process of wound re-epithelialization active.

METHOD FOR USE

Once tissue granulation is complete, GENIX EGI is hydrated and made to adhere to the edges of the lesion. After 12-15 days of application, it is then removed and the epithelial growth below is checked. Its removal will be followed by further applications of GENIX EGI, with progression from the periphery towards the centre, until complete healing.

 

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TECHNICAL SPECIFICATIONS:

- Type I collagen membrane derived from heterologous pericardium

- Dried translucent membrane

- Absorbable

- 200 µm thick

- Biocompatible

- Sterilized by gamma irradiation

- Sterility guaranteed for 5 years

- Packed in blister packs of 3 to 5 strips each,

  1cm x 5 cm

 

BIBLIOGRAPHY

- Sudbeck BD, Parkes WC, Welgus HG, Pentland AP (1994) Collage-stimulated induction of collagenases keratinocytes is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem 269: 30022-29

- Veves A, Sheene P, Hau P (2002) A randomized controlled trial of a collagen / oxidised regenerated cellulose dressing, Promogran, versus standard treatment in the management of diabetic foot ulcers. Arch Surg 137: 822-7

- Wolcott RD, Kennedy JP, Dowd SE (2009) Regular debridement is the main tool for Maintaining a healthy wound bed in most chronic wounds. J Wound Care 18: 54-6

- Equine Pericardium Collagen Wound Dressing in the Treatment of the Neuropathic Diabetic Foot Wound. A Pilot Study. John G. Fleischli, DPM, Terese J. Laughlin, DPM and Jeffery W. Fleischli, DPM. Journal of the American Podiatric Medical Association. Volume 99 Number 4301-305 2009

- E. A. O'Toole - Extracellular matrix and keratinocyte migration, 2001 Blackwell Science Ltd. Clinical and Experimental Dermatology, 26, 525 ± 530

- La Rosa A. Ultrasonic debridement and collagenenic therapy in the management of leg ulcers with a new integrated method. 5th International Workshop on Wound Technology - Paris, January 20 to 22.2013, 59